DISSEMINATED ZYGOMYCOSIS IN A NEUTROPENIC PATIENT - SUCCESSFUL TREATMENT WITH AMPHOTERICIN-B LIPID COMPLEX AND GRANULOCYTE-COLONY-STIMULATING FACTOR

Disseminated zygomycosis in persistently neutropenic patients has been almost uniformly fatal despite aggressive surgical and medical manage ment. We describe a neutropenic patient with disseminated zygomycosis that involved the lungs and kidneys and was successfully treated with amphotericin B lipid complex and granulocyte colony-stimulating factor , followed by suppressive therapy with amphotericin B for 1 pear. This approach preserved the patient's renal function and restored systemic host defenses. The single pulmonary lesion was resected, but no resec tion of renal tissue was attempted because of the bilateral extension of the renal lesions. After a 1-year period of followup without antifu ngal therapy, the patient's condition remains stable, and there has be en no relapse of the infection.