We describe the first documented case of Mycoplasma felis infection in
a woman who had common variable immunodeficiency and who presented wi
th septic arthritis of the left hip and right knee. M. felis was isola
ted from both joints. She had been exposed to cats before the diagnosi
s of M. felis septic arthritis was made, Both of the patient's joints
were surgically debrided, and she was treated with doxycycline for sev
eral months. In spite of initial improvement, destruction of her hip w
as noted, Subsequently, she underwent hip arthroplasty; histopathologi
cal examination of the bone at the time of surgery showed chronic oste
omyelitis, and doxycycline therapy was continued.