We review the etiologic agents, epidemiology, pathogenesis, pathology,
clinical manifestations, and imaging features of several unusual intr
acranial infections that have not been discussed elsewhere in this iss
ue. The central nervous system (CNS) infections discussed are Creutzfe
ldt-Jakob disease (CrJaD), neurosyphilis, primary amebic meningoenceph
alitis (PAM), granulomatous amebic encephalitis (GAE), cerebral amebia
sis, and cerebral hydatid disease.