A SUCCINCT ASYMMETRIC-SYNTHESIS OF (2S,3R)-2-METHYL-3-AMINOPENTANOIC ACID HYDROCHLORIDE

Authors
DAVIES SG ICHIHARA O WALTERS IAS
Citation
Sg. Davies et al., A SUCCINCT ASYMMETRIC-SYNTHESIS OF (2S,3R)-2-METHYL-3-AMINOPENTANOIC ACID HYDROCHLORIDE, Synlett, (2), 1994, pp. 117-118
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
2
Year of publication
1994
Pages
117 - 118
Database
ISI
SICI code
0936-5214(1994):2<117:ASAO(A>2.0.ZU;2-M
Abstract
The highly stereoselective conjugate addition of lithium (R)-(alpha-me thylbenzyl)benzylamide (R)-2 to tert-butyl (E)-2-methyl-2-pentenoate 3 affords a-straightforward synthesis of (2S,3R)-2-methyl-3-aminopentan oic acid 1 as its hydrochloride salt 5.