In most animals there is bilateral access of odorants to the olfactory
sensory epithelium. Air enters the nose through two external nares an
d passes back through the nasal cavity, which is divided down the midl
ine by a cartilaginous nasal septum. The olfactory mucosa, a sheet of
ciliated bipolar receptor cells, is found in the caudal two thirds of
the nasal cavity. Axons from the sensory cells project to an ipsilater
al extension of the telencephalon known as the olfactory bulb. If a si
ngle external naris of a rat pup is surgically closed (usually via bri
ef cauterization) on the day after the day of birth (Pi) and the subje
ct is examined on P30, the size of the ipsilateral olfactory bulb is r
educed by approximately 25%. The large reduction in size, coupled with
the clear lamination and other features of the olfactory system, indi
cates that the manipulation is an ideal preparation for examining the
regulation of early growth. We know that both olfactory bulbs are of e
qual size at the time of occlusion, but that 30 days later there is a
large discrepancy. What series of events produces the changes? The pre
sent paper outlines what is known about the anatomical, biochemical an
d physiological changes introduced by naris occlusion in order to lay
a framework for further work.