CYSTEINE STRING PROTEINS - A POTENTIAL LINK BETWEEN SYNAPTIC VESICLESAND PRESYNAPTIC CA2+ CHANNELS

Authors
MASTROGIACOMO A PARSONS SM ZAMPIGHI GA JENDEN DJ UMBACH JA GUNDERSEN CB
Citation
A. Mastrogiacomo et al., CYSTEINE STRING PROTEINS - A POTENTIAL LINK BETWEEN SYNAPTIC VESICLESAND PRESYNAPTIC CA2+ CHANNELS, Science, 263(5149), 1994, pp. 981-982
Citations number
28
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
263
Issue
5149
Year of publication
1994
Pages
981 - 982
Database
ISI
SICI code
0036-8075(1994)263:5149<981:CSP-AP>2.0.ZU;2-I
Abstract
Presynaptic calcium channels are key regulators of neurotransmitter re lease. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels. Subcellular f ractionation revealed that cysteine string proteins copurify with syna ptic vesicles. An average vesicle had eight protein monomers with both the amino and carboxyl termini detected on the cytoplasmic face. Thus , docked synaptic vesicles may regulate presynaptic calcium channels a nd neurotransmitter release.