IMPAIRMENT OF THE HUMAN PHAGOCYTE OXIDATIVE RESPONSES CAUSED BY LEISHMANIA LIPOPHOSPHOGLYCAN (LPG) - IN-VITRO STUDIES

Authors
BRANDONISIO O PANARO MA MARZIO R MARANGI A FALIERO SM JIRILLO E
Citation
O. Brandonisio et al., IMPAIRMENT OF THE HUMAN PHAGOCYTE OXIDATIVE RESPONSES CAUSED BY LEISHMANIA LIPOPHOSPHOGLYCAN (LPG) - IN-VITRO STUDIES, FEMS immunology and medical microbiology, 8(1), 1994, pp. 57-62
Citations number
24
Categorie Soggetti
Immunology,Microbiology
Journal title
FEMS immunology and medical microbiology → ACNP
ISSN journal
09288244
Volume
8
Issue
1
Year of publication
1994
Pages
57 - 62
Database
ISI
SICI code
0928-8244(1994)8:1<57:IOTHPO>2.0.ZU;2-8
Abstract
Lipophosphoglycan (LPG), a surface glycoconjugate of Leishmania promas tigotes, has been reported as playing an active role in protecting the parasite within phagolysosomes, by an impairment of monocyte oxidativ e responses. In this study the effect of LPG on the oxidative burst of human peripheral monocytes, eosinophils and neutrophils was evaluated . Our results demonstrated that either superoxide anion (O-2(-)) or hy drogen peroxide (H2O2) release by LPG-pretreated cells was diminished, emphasizing the ability of this glycoconjugate to impair the oxidativ e activity of all phagocytes.