Screening mammography continues to play a key role in the early diagno
sis of non-palpable breast cancer. Approximately 5% of patients will h
ave lesions on their mammograms that appear neither clearly benign nor
malignant. The proper management of these patients is not well define
d. In this study, the mammograms of 64 women who underwent breast biop
sy were reviewed. After the initial review, the mammograms were reeval
uated using a personal computer driven digital conversion and enhancem
ent system. The majority of indeterminate lesions were assigned a dete
rminate diagnosis by enhancing the areas of abnormality through enlarg
ement, contrast adjustment, and brightness adjustment. The radiologist
s were able to maintain baseline sensitivity and specificity throughou
t this process. In contrast, enhancement of lesions initially assigned
a diagnosis of characteristically benign or malignant demonstrated no
advantage over plain film mammography. These findings suggest a role
for the selective use of digital mammography and enhancement technique
s. (C) 1994 Wiley-Liss, Inc.