A group of 15 calves, clinically affected by sarcoptic mange, was stud
ied from June to September 1991 in a farm next to Valdivia, 10(th) Reg
ion, Chile, Nine calves were treated subcutaneously with 0.2 mg/kg of
moxidectin on days 1 and 42 of the trial and the other six calves were
treated on day 42. Both groups remained together all the time. In the
calves treated on day 1, cutaneous lesions decreased, but most skin s
amples remained positive to mites up to day 42 of the trial; the mean
weight gain of the group was 269.8 g/day in this period. After the sec
ond treatment, on day 42, a rapid involution of the skin lesions was o
bserved and the mites disappeared; during this period the group presen
ted a mean weight gain of 301.6 g/day. The other six calves, treated o
nly on day 42, were positive to mites until a week after the treatment
; the mean weight gain till day 42 was 35.7 g/day. After the treatment
, an involution of the cutaneous lesions was observed and the mean wei
ght gain was 314.8 g/day.