PNEUMOCYSTIS-CARINII PNEUMONIA UNDER THER APY WITH 2-CHLORODEOXYADENOSINE (2-CDA)

Authors
HABERTHUR C PLESS M TICHELLI A GRATWOHL A SPECK B BETTICHER DC
Citation
C. Haberthur et al., PNEUMOCYSTIS-CARINII PNEUMONIA UNDER THER APY WITH 2-CHLORODEOXYADENOSINE (2-CDA), Schweizerische medizinische Wochenschrift, 124(1-2), 1994, pp. 73-78
Citations number
54
Categorie Soggetti
Medicine, General & Internal
Journal title
Schweizerische medizinische Wochenschrift → ACNP
ISSN journal
00367672
Volume
124
Issue
1-2
Year of publication
1994
Pages
73 - 78
Database
ISI
SICI code
0036-7672(1994)124:1-2<73:PPUTAW>2.0.ZU;2-D
Abstract
We report the case of a 70-year-old patient with B-cell chronic lympho cytic leukemia. During therapy with the new purine analog 2-chlorodeox yadenosine (2-CDA) the patient developed Pneumocystis carinii pneumoni a (PCP). Although the mechanism of action of 2-CDA suggests the incide nce of opportunistic infections and therefore pneumocystis pneumonia, this is the first case of PCP among 140 patients of the Swiss study of 2-CDA. The mechanism of action of 2-CDA is described and the occurren ce of PCP among patients without acquired immunodeficiency syndrome is discussed.