MULTIPLE NONMELANOMA SKIN-CANCER - EVIDENCE THAT DIFFERENT MHC GENES ARE ASSOCIATED WITH DIFFERENT CANCERS

HLA DR frequencies of patients with multiple non-melanoma skin cancers were analysed. There were significant differences in the frequencies of HLA DR1, DR4 and DR7 between patients who only had basal cell carci nomas and patients who had both basal and squamous cell carcinomas. Th ere were significant differences in the frequency of HLA DR53 between the two groups. This antigen is in linkage disequilibrium with HLA DR4 and DR7, and it is not possible to distinguish the primary susceptibi lity locus.