GROWTH-FACTORS AND EXTRACELLULAR SIGNAL-REGULATED KINASES (MITOGEN-ACTIVATED PROTEIN-KINASE) IN THE RAT PINEAL-GLAND

Authors
KIYAMA H WANAKA A KATO H MAENO H MATSUMOTO K SUN GG SHIOSAKA S TOHYAMA M
Citation
H. Kiyama et al., GROWTH-FACTORS AND EXTRACELLULAR SIGNAL-REGULATED KINASES (MITOGEN-ACTIVATED PROTEIN-KINASE) IN THE RAT PINEAL-GLAND, Neuroendocrinology, 59(2), 1994, pp. 152-155
Citations number
26
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuroendocrinology → ACNP
ISSN journal
00283835
Volume
59
Issue
2
Year of publication
1994
Pages
152 - 155
Database
ISI
SICI code
0028-3835(1994)59:2<152:GAESK(>2.0.ZU;2-D
Abstract
The present study revealed that the pineal gland expressed basic fibro blast growth factor (bFGF) and FGF-receptor 1 (FGFR1/flg), suggesting that bFGF in the pineal gland acts in an autocrine or paracrine manner , which is mediated by FGFR1/flg. The present study also examined gene expression of the extracellular signal-regulated kinase (ERK) family (ERK1-3) which may be intracellular signal mediators of growth factors . ERK1 [mitogen-activated protein kinase (MAP-kinase)] was strongly ex pressed throughout the pineal gland, while expression of ERK2 and ERK3 was not found. These findings suggest the presence of a signal pathwa y from bFGF to ERK1 via FGFR1/flg in the pineal gland.