CONVERSION OF CORTICOSTEROID HORMONES BY IMMOBILIZED CELLS OF FLAVOBACTERIUM DEHYDROGENANS, CURVULARIA-LUNATA AND ARTHROBACTER SIMPLEX ON CERAMIC CARRIERS

Authors
SPASSOV G PRAMATAROVA V WANDREY C
Citation
G. Spassov et al., CONVERSION OF CORTICOSTEROID HORMONES BY IMMOBILIZED CELLS OF FLAVOBACTERIUM DEHYDROGENANS, CURVULARIA-LUNATA AND ARTHROBACTER SIMPLEX ON CERAMIC CARRIERS, Applied microbiology and biotechnology, 46(5-6), 1996, pp. 481-488
Citations number
19
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Applied microbiology and biotechnology → ACNP
ISSN journal
01757598
Volume
46
Issue
5-6
Year of publication
1996
Pages
481 - 488
Database
ISI
SICI code
0175-7598(1996)46:5-6<481:COCHBI>2.0.ZU;2-R
Abstract
Different possibilities for converting pregnenolone triacetate to pred nisolone using immobilized preparations of Flavobacterium dehydrogenan s, Curvularia lunata and Arthrobacter simpelex in a fixed-bed loop rea ctor were investigated. The effects of the carrier, substrate concentr ation, pH and temperature on the rate of the substrate conversion were studied also, The biotransformations were performed with a continuous or semicontinuous substrate supply. A convenient pathway for the form ation of prednisolone is proposed on the basis of the results obtained .