DESIGN AND SYNTHESIS OF NOVEL PEPTIDES BEARING A HOST AND A GUEST SIDE-CHAINS

The synthesis of model heptapeptides bearing a host and a guest side c hains at different positions is reported. These peptidic structures we re designed in such a way that specific backbone; conformations could be induced and stabilized by cooperative side chain interactions. Alth ough circular dichroism studies demonstrated that intra- and intermole cular host guest interactions are involved in the stabilization of the peptidic conformation, they are not strong enough to induce a complet e conformational reorganization.