GLUCOREGULATION AND HORMONAL CHANGES DURING PROLONGED EXERCISE IN BOYS AND GIRLS

A group of 17 children, 8.5-11 years old, performed a 60-min cycle exe rcise at 60% of maximal oxygen uptake (VO2max) 2h after a standardized breakfast. They were 10 young boys (pubertal stage =1) and 7 young gi rls (pubertal stage less than or equal to 2) of similar VO2max (respec tive values were 48,5 mi min(-1) kg(-1), SEM 1.8; 42.1 mi min(-1) kg(- 1), SEM 2.4). Blood samples of 5 mi were withdrawn by heparinized cath eter, the subjects being in a supine position, 30 min before the test, then after 0, 15, 30 and 60 min of exercise and following 30 min reco very. Haematocrit was immediately measured. Thereafter plasma was anal ysed for glucose, nonesterified fatty acid, glycerol, catecholamine (n oradrenaline, adrenaline), insulin and glucagon concentrations. This s tudy showed two main results. First, the onset of exercise induced a s ignificant glucose decrease (of about 11,4%) in all the children. Seco ndly, both the glycaemic and the hormonal responses were obviously dif ferent according to the sex. In boys only, the initial glucose drop wa s significantly correlated to the pre-exercise insulin values. Whateve r the time, the glycaemic levels and the catecholamine responses were lower in girls than in boys, whereas the insulin values remained highe r. However, none of these two hormonal parameters seemed to be really responsible for the lower glucose values in girls. On the one hand, th e great individual variability of noradrenaline and adrenaline and dif ferences in their relative intensity at the end of the exercise betwee n boys and girls might contribute to the lower catecholamine levels in girls. On the other hand, the lack of a significant relationship in g irls between the glucose decrease after exercise and the pre-exercise insulin values might be explained by a relative insulin insensitivity concomitant with the earlier growth spurt in girls, as demonstrated in subjects at rest by other authors. Finally the mechanisms of all thes e gender differences remain to be clarified and might be accounted for by a different maturation level in boys and girls.