ANTIINFLAMMATORY KETOPROFEN IN THE TREATMENT OF FIELD CASES OF BOVINEMASTITIS

The efficacy of ketoprofen in the treatment of acute clinical mastitis was evaluated in a clinical trial comprising a non-blind controlled s tudy and a blind, placebo-controlled study. All the cows mere treated with 20 g sulphadiazine and 4 g trimethoprim intramuscularly upon diag nosis, and half the dosage was given once daily thereafter. In additio n, the ketoprofen treatment groups received 2 g ketoprofen intramuscul arly once daily for the duration of the antimicrobial therapy. Recover y rates for the non-blind contemporary controls and the blind placebo- controls mere 83.7 per cent and 70.7 per cent, respectively. In the no n-blind controlled ketoprofen and the placebo-controlled ketoprofen tr eatment groups, recovery rates were 94.7 per cent and 92.3 per cent, r espectively. The odds ratio (OR) of recovery was significantly (P less than or equal to 0.01) high in the placebo-controlled study (OR = 6.7 5, confidence interval [CI] = 1.45 to 31.4), and high but not signific ant in the non-blind controlled study (OR = 2.64, CI = 0.53 to 13.10). It was concluded that ketoprofen significantly improved recovery in c linical mastitis in dairy cows.