Kjao. Ingels et al., INFLUENCE OF COCAINE AND LIDOCAINE ON HUMAN NASAL CILIA - BEAT FREQUENCY AND HARMONY IN-VITRO, Archives of otolaryngology, head & neck surgery, 120(2), 1994, pp. 197-201
The effects of cocaine and lidocaine on ciliary beat frequency and cil
iary beat harmony were studied in biopsy specimens of normal human nas
al mucosa. Cocaine was investigated in increasing concentrations (0.87
5%, 1.75%, 3.5%, and 7%) in five samples; lidocaine (0.125%, 0.25%, 0.
5%, 1%, and 2%), in four samples. Ciliary beat was recorded photoelect
rically and the signal was analyzed. Cocaine was found to decrease cil
iary beat frequency and ciliary beat harmony at concentrations of 1.75
% and higher. Partially reversible ciliostasis was seen at 7%. Lidocai
ne was found to decrease ciliary beat frequency and ciliary beat harmo
ny at concentrations of 0.25% and higher. Irreversible ciliostasis was
seen at 2%. Cocaine and lidocaine affected ciliary beat frequency and
ciliary beat harmony in the same way.