ABLATION OF LUTEAL-PHASE SYMPTOMS OF MENIERES-DISEASE WITH LEUPROLIDE

Symptoms of Meniere's disease in women may be exacerbated during the l uteal phase of the menstrual cycle. This suggests a role for progester one production and subsequent fluid redistribution as a predisposing f actor for Meniere's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Meni ere's symptoms. This drug, which abolishes gonadotropin-dependent ovar ian sex steroid production, alleviated the patient's symptoms during t herapy. This observation offers further support to the hypothesis of s ex hormone-related exacerbations of Meniere's symptoms and provides a possible future treatment option for this debilitating disease.