HIGH F1.2 FRAGMENT OF PROTHROMBIN, THROMBIN-ANTITHROMBIN-III COMPLEX (TAT) AND SOLUBLE FIBRIN PLASMA-LEVELS DEMONSTRATE HYPERCOAGULABILITY INDUCED DURING LOCO-REGIONAL THROMBOLYTIC THERAPY WITH RT-PA
A. Garciaavello et al., HIGH F1.2 FRAGMENT OF PROTHROMBIN, THROMBIN-ANTITHROMBIN-III COMPLEX (TAT) AND SOLUBLE FIBRIN PLASMA-LEVELS DEMONSTRATE HYPERCOAGULABILITY INDUCED DURING LOCO-REGIONAL THROMBOLYTIC THERAPY WITH RT-PA, Thrombosis research, 73(2), 1994, pp. 109-115
In order to investigate the coagulation and fibrinolysis state in arte
rial peripheral thrombosis and thrombolysis, we studied 33 consecutive
patients (mean age=65, range: 28-88), 25 males and 8 females diagnose
d of acute or subacute lower limb arterial thrombosis, treated with an
intrathrombus infusion of rt-PA (0.1 mg/Kg/h) for three hours. Plasma
levels of antithrombin III (ATIII), protein C (PC), plasminogen (Pg)
and alpha(2)-antiplasmin (AP), total and free protein S (PS), thrombin
-antithrombin III complex (TAT), F1.2 fragment of prothrombin (F1.2),
fibrinogen (Fg), soluble fibrin monomers (FM), tissue-plasminogen acti
vator (t-PA), plasminogen activator inhibitor 1 (PAI-1), total fibrino
gen/fibrin degradation products (TDP) and D dimer (DD) were determined
prior to the therapeutic regime, at the end of the treatment, and 24
hours later. Levels of AT-III and protein C were somewhat low during t
he complete study. There was an increase in t-PA, TDP and D Dimer and
a decrease of fibrinogen, alpha,antiplasmin and plasminogen at 3 hours
. An elevation of TAT, fibrin monomers and F1.2 levels was found at th
ree hours. A positive correlation between TAT and F1.2 was observed (r
=0.57, p<0.05). There was also a positive correlation between soluble
fibrin and TAT (r=0.59, p<0.05) and with F1.2 (r=0.56. p<0.05). These
latter facts reflect an hypercoagulable situation induced during loco-
regional thrombolytic therapy.