SYNTHESIS OF [5-METHYL-H-3]-NITRENDIPINE

Authors
WU DH WANG W
Citation
Dh. Wu et W. Wang, SYNTHESIS OF [5-METHYL-H-3]-NITRENDIPINE, Journal of labelled compounds & radiopharmaceuticals, 39(2), 1997, pp. 105-107
Citations number
8
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
2
Year of publication
1997
Pages
105 - 107
Database
ISI
SICI code
0362-4803(1997)39:2<105:SO[>2.0.ZU;2-F
Abstract
Synthesis of [5-methyl-H-3]-nitrendipine by means of a new method was described. Methyl-[H-3]methanol was reacted with diketene forming meth yl-[H-3]acetoacetate, followed by treatment with ammonia to give [meth yl-H-3]-3-aminoacrotonate, which was reacted with methyl 2-[(3-nitroph enyl)-3-methylene]-3-oxobutanoate to synthesize [5-methyl-H-3]-nitrend ipine. Its specific activity and radiochemical purify were 23 Ci/mmol and >98%, respectively.