SYNTHESIS OF THE MONOSODIUM SALT OF C-14-LABELED PACLITAXEL (TAXOL(R)) 2'-ETHYL CARBONATE 7-PHOSPHONOOXYMETHYL ETHER, A POTENTIAL PRODRUG OF PACLITAXEL

Authors
DISCHINO DD CHEN SH GOLIK J WALKER DW WONG HSL
Citation
Dd. Dischino et al., SYNTHESIS OF THE MONOSODIUM SALT OF C-14-LABELED PACLITAXEL (TAXOL(R)) 2'-ETHYL CARBONATE 7-PHOSPHONOOXYMETHYL ETHER, A POTENTIAL PRODRUG OF PACLITAXEL, Journal of labelled compounds & radiopharmaceuticals, 39(2), 1997, pp. 173-179
Citations number
10
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
2
Year of publication
1997
Pages
173 - 179
Database
ISI
SICI code
0362-4803(1997)39:2<173:SOTMSO>2.0.ZU;2-U
Abstract
The monosodium salt of Carbon-14 labeled paclitaxel (Taxol(R)) [N3'-(1 4)COPh] 2'-ethyl carbonate 7-phosphonooxymethyl ether, was prepared fr om C-14 labeled paclitaxel [N3'-(14)COPh] in 5 steps. The radiochemica l purity of the final product was greater than 99% and the specific ac tivity was 25 mu Ci/mg.