COMBINATORIALLY SELECTED GUANOSINE-QUARTET STRUCTURE IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE-MEDIATED CELL-FUSION

Authors
WYATT JR VICKERS TA ROBERSON JL BUCKHEIT RW KLIMKAIT T DEBAETS E DAVIS PW RAYNER B IMBACH JL ECKER DJ
Citation
Jr. Wyatt et al., COMBINATORIALLY SELECTED GUANOSINE-QUARTET STRUCTURE IS A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE-MEDIATED CELL-FUSION, Proceedings of the National Academy of Sciences of the United Statesof America, 91(4), 1994, pp. 1356-1360
Citations number
37
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
91
Issue
4
Year of publication
1994
Pages
1356 - 1360
Database
ISI
SICI code
0027-8424(1994)91:4<1356:CSGSIA>2.0.ZU;2-B
Abstract
The phosphorothioate oligonucleotide T(2)G(4)T(2) was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a l ibrary of phosphorothioate oligonucleotides that contained all possibl e octanucleotide sequences. The oligonucleotide forms a parallel-stran ded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The t etramer binds to the human immunodeficiency virus envelope protein gp1 20 at the V3 loop and inhibits both cell to-cell and virus-to cell inf ection.