INCREASED SYSTEMIC BIOAVAILABILITY OF ALBENDAZOL WHEN ADMINISTERED WITH SURFACTANTS IN RATS

This work describes the determination of the plasma concentrations of albendazol sulfoxide (ABZ.SO) after administration of single oral dose s of albendazol (ABZ) using surfactants as vehicles (Tween 80 and sodi um taurocholate). The pharmacokinetic parameters AUC, C-max and t(max) were affected by the use of surfactants. The results showed higher pl asma levels of ABZ.SO and the ratio, AUC/initial dose, was 60-100-time s greater in the presence of surfactants.