(186)RHENIUM-HNK1 MONOCLONAL-ANTIBODY TARGETS HUMAN SMALL-CELL LUNG-CANCER CELLS IN ATHYMIC NUDE-MICE - RAPID SCREENING MODEL FOR THERAPY

A model is described by which in vivo tumor-MOAB interactions may be i nvestigated The method is rapid and may aid in the selection of approp riate MOABS from a panel of MOABS for indivi,dualized patient treatmen t. Groups of athymic nude mice were injected intravenously with small cell lung cancer line SHP-77 cells which are trapped primarily in the lungs. Twenty-four hours post tumor cell inoculation (186)Rhenium tagg ed HNK1 MOAB (CD57) was injected intravenously. Controls which receive d no tumor cells were injected with unbound Re-186 or radioactive MOAB . Biodistribution studies at 24 hours following MOAB injection showed significantly more radioactivity in lungs of mice inoculated with both SHP-77 cells and Re-186 MOAB than did lungs of controls.