PENTOSAN INHIBITS ANGIOGENESIS IN-VITRO AND SUPPRESSES PROSTATE TUMOR-GROWTH IN-VIVO

Pentosan polysulfate (PPS) is a highly negatively charged polysacchari de which has activity against multiple tumor types in the preclinical setting. We demonstrate here that Pentosan inhibits the growth of the anaplastic Dunning R3327 rat prostate adenocarcinoma MAT-LyLu when tre atment was started when the tumor was not palpable but has little effe ct against established tumors. This inhibition may be mediated by the effect of Pentosan on endothelial cells. Pentosan, in combination with hydrocortisone, inhibits endothelial cell motility and tubule formati on in vitro and inhibits capillary formation in the chicken chorioalla ntoic membrane (CAM) assay. These data suggest that Pentosan may be a potent inhibitor of tumor-associated angiogenesis and may be an effect ive agent for the prevention and/or suppression of prostate cancer gro wth.