THE EFFICACY OF PHLORHIZIN AND PHLORETIN ON TUMOR-CELL GROWTH

This study utilized phloridzin (P1) and its aglucone phloretin (P2), t wo known inhibitors of glucose transmembrane transport, to inhibit tum or cell growth in vivo. The efficacy of hydrazine sulfate as an antica chexic agent was also evaluated. Utilizing the rat mammary adenocarcin oma and Fischer bladder cell carcinoma cell lines, it has been shown t hat the i.p. administration of P1 and P2 can produce significant diffe rences in mean tumor diameters as compared to the untreated controls.