PHLORHIZIN AND PHLORETIN INHIBITION OF 2-DEOXY-D-GLUCOSE UPTAKE BY TUMOR-CELLS IN-VITRO AND IN-VIVO

Utilizing the rat mammary adenocarcinoma and Fischer bladder cell carc inoma cell lines, this study demonstrated the ability of two known glu cose transport inhibitors, phloridzin (P1) and its aglucone, phloretin (P2), to block glucose transport into whole viable tumor cells in vit ro and tumor tissues in vivo. This work represents the first in a seri es of experiments designed to explore the efficacy of P1 and P2 admini stration in restraining tumor cell growth via the inhibition of glucos e transmembrane transport.