COMPARATIVE-STUDY OF THE ANTITUMOR-ACTIVITY OF BISTRAMIDES A, D AND KAGAINST A NONSMALL CELL BRONCHOPULMONARY CARCINOMA

Bistramides A, D and K are substances extracted from the marine ascidi an Lissoclinum bistratum Sluiter that are capable of inducing in vitro terminal differentiation (G1DT) of cells from a non-small cell bronch o-pulmonary carcinoma (NSCLCN(6)), but present different in vitro toxi cities. This study shows that only the least toxic bistramides D and K possess an antitumor activity. These true substances could be adminis tered as a continuous treatment which would induce terminal differenti ation of stem cells at their entry into the cell cycle, thereby causin g their destruction.