PHOTOCHEMICAL-SYNTHESIS OF SPIROCYCLOHEXYLISOQUINOLINES, ANALOGS OF (+ -)-GALANTHAMINE AND (+/-)-LYCORAMINE/

Authors
MISSOUM A SINIBALDI ME VALLEEGOYET D GRAMAIN JC
Citation
A. Missoum et al., PHOTOCHEMICAL-SYNTHESIS OF SPIROCYCLOHEXYLISOQUINOLINES, ANALOGS OF (+ -)-GALANTHAMINE AND (+/-)-LYCORAMINE/, Synthetic communications, 27(3), 1997, pp. 453-466
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
3
Year of publication
1997
Pages
453 - 466
Database
ISI
SICI code
0039-7911(1997)27:3<453:POSAO(>2.0.ZU;2-P
Abstract
Photocyclization of N-arylenamides 10, 15 and 16 led efficiently to sp irotricyclic delta-lactams 5, 6 and 7. Compound 7 was easily and stere ospecifically transformed in two steps into spirocyclohexylisoquinolin es 3 and 4 which show structural analogies with some Amaryllidaceae al kaloids, galanthamine 1 and lycoramine 2.