BOTH MATERNAL AND FETAL GENETIC-FACTORS CONTRIBUTE TO MACROSOMIA OF DIABETIC PREGNANCY

The study of 230 diabetic mothers along with their newborn babies has shown that foetal macrosomia is associated with two specific genomic s ites: phosphoglucomutase locus 1 (PGM(1))-Rhesus blood group (Rh) link age group (chromosome 1) and HindIII restriction fragment length polym orphism (RFLP) linked to insulin-like growth factor 1 (IGF1) (chromoso me 12). In PGM(1)2-1 mothers carrying the E allele, there is a proport ion of 8.7% of macrosomic newborns as compared with 39.6% in mothers w ith other genotypes. The relationship between the maternal PGM(1)-RhE genotype and neonatal macrosomia does not depend on the type of diabet es. The proportion of macrosomic infants is much lower among newborns carrying the IGF1H(S) allele of the HindIII RFLP linked to IGF1 (20%) than among IGF1(F)/IGF1H(F) newborns (55%).