LINKAGE ANALYSIS IN NUCLEAR FAMILIES .2. RELATIONSHIP BETWEEN AFFECTED SIB-PAIR TESTS AND LOD SCORE ANALYSIS

Authors
KNAPP M SEUCHTER SA BAUR MP
Citation
M. Knapp et al., LINKAGE ANALYSIS IN NUCLEAR FAMILIES .2. RELATIONSHIP BETWEEN AFFECTED SIB-PAIR TESTS AND LOD SCORE ANALYSIS, Human heredity, 44(1), 1994, pp. 44-51
Citations number
12
Categorie Soggetti
Genetics & Heredity
Journal title
Human heredity → ACNP
ISSN journal
00015652
Volume
44
Issue
1
Year of publication
1994
Pages
44 - 51
Database
ISI
SICI code
0001-5652(1994)44:1<44:LAINF.>2.0.ZU;2-M
Abstract
It is believed that the main advantage of affected sib-pair tests is t hat their application requires no information about the underlying gen etic mechanism of the disease. However, here it is proved that the mea n test, which can be considered the most prominent of the affected sib -pair tests, is equivalent to lod score analysis for an assumed recess ive mode of inheritance, irrespective of the true mode of the disease. Further relationships of certain sib-pair tests and lod score analysi s under specific assumed genetic modes are investigated.