SEROTONIN IN PANIC DISORDER AND SOCIAL PHOBIA

The role of serotonin in psychiatry has been the focus of speculation for several decades. The literature since 1966 is reviewed (and refere nced) and five organizing questions are identified: (1) What are the m ajor hypotheses regarding the involvement of the serotonin system in p anic disorder? (2) Is there a serotonin system defect associated with panic disorder? (3) Is a serotonin system defect the cause of panic di sorder? (4) Are the 5-HT1A agonists and the 5-HT2 antagonists effectiv e in this condition? (5) Are serotonin selective uptake inhibitors (SS UIs) effective in panic disorder via the serotonin system or some othe r mechanism? Though the role of the serotonin system in panic disorder and social phobia is uncertain there is increasing agreement that SSU Is effectively treat panic disorder but further double-blind placebo-c ontrolled studies are needed.