Dermatomyositis (DM) developed in a 35-year-old woman after 2 months o
f psoralen ultraviolet-A (PUVA) therapy for presumed psoriasis. Her di
sease was characterized by symmetrical proximal muscle weakness and cu
taneous lesions compatible with DM. In addition, laboratory abnormalit
ies included a positive antinuclear antibody, and elevated levels of c
reatine kinase and aldolase. This is the first report of DM developing
during PUVA therapy.