MOLECULAR ABNORMALITY OF A UNIQUE JAPANESE GLUCOSE-6-PHOSPHATE-DEHYDROGENASE VARIANT (G6PD KOBE) WITH A GREATLY INCREASED AFFINITY FOR GALACTOSE-6-PHOSPHATE

Authors
HIRONO A NAKAYAMA S FUJII H MIWA S
Citation
A. Hirono et al., MOLECULAR ABNORMALITY OF A UNIQUE JAPANESE GLUCOSE-6-PHOSPHATE-DEHYDROGENASE VARIANT (G6PD KOBE) WITH A GREATLY INCREASED AFFINITY FOR GALACTOSE-6-PHOSPHATE, American journal of hematology, 45(2), 1994, pp. 185-186
Citations number
10
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
45
Issue
2
Year of publication
1994
Pages
185 - 186
Database
ISI
SICI code
0361-8609(1994)45:2<185:MAOAUJ>2.0.ZU;2-D
Abstract
Systematic molecular analysis of a Japanese class 1 glucose-6-phosphat e dehydrogenase (G6PD) variant (GGPD Kobe) cDNA revealed a unique nucl eotide substitution(1318 C to T) in exon 11, which predicts a substitu tion of leucine for phenylalanine at residue 440. This substitution is located in a region surrounding the putative structural NADP-binding domain. The markedly abnormal kinetics of glucose-g-phosphate (G6P) of GGPD Kobe suggest the interaction between both NADP and G6P binding s ites. (C) 1994 Wiley-Liss, Inc.