ARGYROPHIL CELL HYPERPLASIA AND A CARCINOID-TUMOR IN THE STOMACH OF APATIENT WITH SPORADIC ZOLLINGER-ELLISON SYNDROME

In the rat, hypergastrinaemia induced by drug treatment with omeprazol e or potent H-2-receptor antagonists leads to the development of gastr ic enterochromaffin-like cell carcinoids. In man, gastric carcinoids i nduced by hypergastrinaemia have been described only in patients with chronic atrophic gastritis type A and in patients with the multiple en docrine neoplasia syndrome type 1. This patient with Zollinger-Ellison syndrome without gastric mucosal atrophy and without evidence of the multiple endocrine neoplasia syndrome developed an argyrophil gastric carcinoid tumour. This observation indicates that hypergastrinaemia in the sporadic Zollinger-Ellison-syndrome may induce gastric-carcinoids .