ANTIMICROBIAL EFFECTS OF NEWLY SYNTHESIZED ORGANOTIN(IV) AND ORGANOLEAD(IV) DERIVATIVES

Triorganotin(IV) and triorganolead(IV) derivatives of the types Me3Sn( SCZ) and Ph3Pb(SCZ) (where SCZ- is the anion of a semicarbazone ligand ) have been synthesized by substitution reactions of trimethyltin chlo ride and triphenyl-lead chloride with semicarbazones derived from hete rocyclic ketones. The resulting complexes have been characterized by e lemental analyses, molecular weight determinations and conductivity me asurements. The mode of bonding has been established on the basis of i nfrared and H-1, C-13 and Sn-119 NMR spectroscopic studies. Some respr esentative complexes have also been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria; the res ults of these investigations have been reported in the present paper.