MOVING RIGHT ALONG - REGULATION OF CELL-MIGRATION DURING DROSOPHILA DEVELOPMENT

Cell movement is a fascinating feature of animal development. Genetic approaches have recently led to the identification of regulatory prote ins required for specific cell migrations in development of the mouse, nematode and fruitfly. Here, I focus on two model systems for genetic studies of cell migration during Drosophila development: migration of follicle cells in the ovary and migration of tracheal cells in the em bryo. Mutations that affect these migrations have allowed the identifi cation of transcription factors and an FGF receptor homolog as importa nt regulators of cell migration. Signaling through receptor tyrosine k inases may be a general mechanism for the regulation of cell movement in development and in metastasis.