ATRIAL-NATRIURETIC-PEPTIDE AND ACUTE MYOCARDIAL-INFARCTION - CRITICALREAPPRAISAL

The present investigation was designed to assess the correlation of at rial natriuretic peptide (ANP) with the ordinary markers of acute myoc ardial infarction (AMI). In 15 patients with uncomplicated AMI, no rem arkable variation in ANP plasma levels was found. On the other hand, s erum myoglobin and cardiac enzymes behaved as usual. Our results show that ANP is not correlated with serum myoglobin, creatine-phosphokinas e and its isoenzyme MB, being completely independent from these marker s of myocardial injury. These observations suggest that the plasma ANP variations observed in AMI by other investigators are probably depend ent on hemodynamic dysfunction.