AMINO-ACIDS AND PEPTIDES .48. STUDIES ON THE STRUCTURE OF AN UNEXPECTED REACTION-PRODUCT FROM DIPEPTIDYL CHLOROMETHYL KETONE DURING ACID-HYDROLYSIS

Authors
YOKOI T TAGUCHI H NISHIYAMA Y IGARASHI K KASUYA F OKADA Y
Citation
T. Yokoi et al., AMINO-ACIDS AND PEPTIDES .48. STUDIES ON THE STRUCTURE OF AN UNEXPECTED REACTION-PRODUCT FROM DIPEPTIDYL CHLOROMETHYL KETONE DURING ACID-HYDROLYSIS, Journal of chemical research. Synopses, (1), 1997, pp. 10-11
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
1
Year of publication
1997
Pages
10 - 11
Database
ISI
SICI code
0308-2342(1997):1<10:AAP.SO>2.0.ZU;2-2
Abstract
During the course of the synthesis of peptidyl chloromethyl ketones (C MKs), it was revealed that aminoacid recovery after acid hydrolysis (6 mol dm(-3) HCl, 110 degrees C, 20 h) of dipeptidyl chloromethyl keton es was markedly low (7.1-33.7%) owing to the formation of 5-methylpyra zin-2(1H)-one derivatives during the acid hydrolysis.