THE ROLE OF THE ENVIRONMENT IN UKRAINE AF TER CHERNOBYL ACCIDENT AND THE GENETIC COMPONENT IN CANCER DEVELOPMENT IN FEMALE REPRODUCTIVE-SYSTEM

An increase in breast cancer and tumors of reproductive organs was rev ealed both in a group of women from the regions which are subject to r adiation control after the Chernobyl NPP accident and a wider group of Ukrainian female population non-restricted to the above region. Geogr aphical distribution of morbidity is demonstrated. Both genetic and en vironmental factors are proved to play a part in the susceptibility to development of breast and corpus uteri cancers. The contribution of e ach of the above factors is assessed. Chromosomal instability was reve aled in endometrium cancer patients, even more pronounced in the indiv iduals with a tumor development history aggregated in families. The ne ed for further investigation of development of cancer against genetic background is underlined.