IMMUNOPHENOTYPING OF PERIPHERAL-BLOOD MON ONUCLEARS IN NON-HODGKINS-LYMPHOMA PATIENTS

19 patients with different morphological variants of non-Hodgkin's lym phoma (NHL) were investigated. Immunophenotype of mononuclears of peri pheral blood (PBL) was examined by monoclonal antibodies to CD3, 4, 5, 7, 8, 10, 16, 22, 25, 34, 38, DR+ and antigen of heavy chain (mu) of IgM. It was revealed that quantitative changes of PBM subpopulations i n patients with NHL III-IV stages were associated with the morphologic al variant of the disease and may be used for defining of T- or B-cell s NHL. The increase in PBM with CD5, 7, 3, 10, 34, 16 antigens is asso ciated with a T-cell variant of NHL. The increase in PBM with CD10, 34 , 25, 38, mu-IgM is associated with a B-cell variant of NHL.