INTERACTION OF CISPLATIN WITH RAT HEPATOC YTE PLASMOLEMMA AND HUMAN SERUM-ALBUMIN

Character of structural effects in rat hepatocyte plasmalemma (HP) and human serum albumin (HSA), which are evoked with cisplatin were studi ed using fluorescent methods. It was established, that in albumin macr omolecules of HP at the action of the preparation took place conformat ional reconstructions, which consisted in the transit of tryptophanyls from the surface into the interior of the macromolecules and in the r everse transition of tyrosyls. Besides, the decrease of the level of a lbumin immersion in the lipid matrix was registered. In HSA cisplatin induced immersion of tryptophanyl residue deep into the albumin globul e.