ANTIMETASTATIC EFFECT OF UKRAIN AND ITS INFLUENCE ON THE OXYGEN AND ENERGY-METABOLISM OF MICE WITH MELANOMA B-16

The influence of intravenous injections of Ukrain (1mg/kg) on the oxyg en tension (pO(2)) in muscle, the oxygen saturation rate and oxygen ut ilization rate as well as on the respiration and oxidative phosphoryla tion indices of the liver mitochondria in mice with melanoma B-16 was studied by polarographic method. Ukrain was shown to improve the oxyge n delivery to the muscular tissue and to decrease a destructive effect of the malignant process on liver bioenergetics. The respiration rate of mitochondria during phosphorylation of exogenous ADP and the respi ratory control coefficient were higher in the treated mice as compared to the untreated tumor-bearing animals. The drug significantly inhibi ted the growth of the primary tumor and its metastasis in lungs.