EXPERIMENTAL-ANALYSIS OF TUMOR-CELLS EXPOSURE TO HIGHLY-DISPERSED FERROMAGNETICS

The study of anticancer effects of highly-dispersed ferromagnetics was performed using experimental in vitro and in vivo models. Heterocoagu lation of tumor cells with ferromagnetic particles was found to be sig nificantly higher as compared to normal cells. Co-incubation of leukem ic P-388 cells in vitro with ferromagnetic particles was accompanied b y a significant inhibition of DNA and RNA syntheses and by a decrease of tumorigenic activity in BDF1 mice. Significant inhibition of Guerin 's carcinoma growth was revealed under both intratumoral and applicati onal administration of ferromagnetics. Our findings support the existe nce of both physicochemical and remote physical (magnetic) mechanisms of highly-dispersed ferromagnetic effects on malignant transformed cel l.