INFLUENCE OF BACTERIAL POLYSACCHARIDES ON ADHESIVE PROPERTIES OF 3LL CARCINOMA-CELLS IN MODEL OF METASTATIC PROCESS IN-VITRO

In model system in vitro using fibroblasts NIH3T3 and basal membrane c omponents produced by them the influence of bacterial polysaccharides (PS) and lipopolysaccharides (LPS) isolated from Clavibacter michigane nse and Pseudomonas solanacearum on adhesive properties of 3LL carcino ma cells has been studied. On the grounds of the data obtained we assu med that PS and LPS studied bound to receptors of tumor cells (TC) and thus blocked the ability of the latters to interact with receptors of basal membrane of fibroblasts. This phenomenon is apparently the basi s of the reduction of TC adhesion under the influence of PS and LPS.