ANALYSIS OF SISTER-CHROMATID EXCHANGE, MICRONUCLEUS AND CHROMOSOMAL ABERRATION FREQUENCIES IN RODENTS EXPOSED TO MOSQUITO COIL SMOKE BY INHALATION ROUTE

Authors
MOORTHY MV MURTHY PB
Citation
Mv. Moorthy et Pb. Murthy, ANALYSIS OF SISTER-CHROMATID EXCHANGE, MICRONUCLEUS AND CHROMOSOMAL ABERRATION FREQUENCIES IN RODENTS EXPOSED TO MOSQUITO COIL SMOKE BY INHALATION ROUTE, Toxicology letters, 70(3), 1994, pp. 357-362
Citations number
13
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
70
Issue
3
Year of publication
1994
Pages
357 - 362
Database
ISI
SICI code
0378-4274(1994)70:3<357:AOSEMA>2.0.ZU;2-H
Abstract
Mosquito coil smoke emitting from a mosquito repellent, was tested for its mutagenic effect in bone marrow cells from mouse and rat after 4 h acute inhalation exposure. Coil smoke with suspended particulate con centrations of 99-129 mg/m(3), significantly elevated the frequencies of sister chromatid exchanges in bone marrow cells and micronuclei in polychromatic erythrocytes. Analysis of chromosomal aberrations in met aphases also revealed a significantly higher incidence of chromosomal aberration frequency in exposed rats and mice.