STABILITY-INDICATING HPLC METHOD FOR RIBAVIRIN AND ITS PHARMACEUTICALDOSAGE FORMS

The present work describes a specific, stability indicating HPLC metho d for determination of Ribavirin (1) and its pharmaceutical dosage for ms. Ribavirin was chromatographed on a microbondapak C18 column utiliz ing a simple mixture of 0.01M dibasic potassium phosphate and methanol (95 : 5). The detection was dpme at 207 nm. The available literature was scanned to locate the various methods(2,3) available along with th e one reported in USP XXII. A comparative study was made of the propos ed method and USP method and the advantages over the USP method have b een discussed. The low value of Relative standard deviation and recove ry of the drug in the range of 99.1% to 101.5% indicates a good precis ion and non-interference of the method.