POLYMERIC PSEUDOLATICES DISPERSION BEARING ISOSORBIDE DINITRATE FOR TRANSDERMAL APPLICATION

A pseudolatex based system for transdermal delivery (PL-ISDN-D) of iso sorbide dinitrate (ISDN) was developed for its prolonged and controlle d systemic availability. To achieve the desired and controlled release rate, different combinations of Eudragit RL-100 and polyvinylpyrrolid one; were used in the preparation of pseudolatices polymeric dispersio ns. These preparations were evaluated for in-vitro release and permeat ion of the drug across human cadavar skin, The designed systems exhibi ted linear relationship between drug release (Q) Vs 0.80 function of t ime (t(0.80)). The product exhibiting required skin permeation (500 mc g/h/ 100 mg) calculated to achieve an effective plasma concentration w as selected for the in-vivo performance evaluation. The drug plasma pr ofile was compared with the plasma profile obtained following the admi nistration of conventional oral dose of isosorbide dinitrate. The stud y revealed that designed pseudolatex transdermal drug delivery system of isosorbide dinitrate could be used successfully with improved perfo rmance.