CONTROLLED DRUG-DELIVERY OF PH DEPENDENT SOLUBLE DRUG PINDOLOL

Pindolol, a pH dependent soluble beta adrenoceptor blocker has been fo rmulated into a controlled drug delivery system. Drug pellets were pre pared by extrusion spheronization technique. These were coated with di fferent retardant polymers, namely ethylcellulose and Eudragit RS 100. The effect of different variables such as coating level and pH of dis solution medium have been studied. Drug release from pellets were foun d to be influenced by the pH of the dissolution medium. A flux release of the drug in the acidic buffer was observed from pellets coated wit h these polymers. To avoid this flux, a top coat using different pH se nsitive polymers, namely Hydroxypropylmethyl cellulose phthalate (HPMC P 55) and Eudragit S 100 was successfully attempted and the drug relea se from the pellets was modified.