BIOCHEMICAL ASPECTS AND STRUCTURAL CHARACTERIZATION OF SULFUR BONDED OXOVANADIUM(V) AND MANGANESE(II) COMPLEXES

The preparation, characterisation and biological activities of some ox ovanadium(V) and manganese(II) complexes of ligands having nitrogen su lphur donor sets are described. Reaction of VOCl3 and MnCl2 with HTSCZ (HTSCZ = thiosemicarbazone) resulted in the formation of complexes of the type [VOCl2(TSCZ)], [MnCl(TSCZ)H2O], [VOCl(TSCZ)2] and [Mn(TSCZ)2 ]. These have been characterized by elemental analyses, molecular weig ht determinations and conductivity measurements and found to be monome ric and nonelectrolytes. Distorted trigonal bipyramidal (1:1) and octa hedral (1:2) geometries for the vanadium(V) complexes and a tetrahedra l geometry for the manganese(II) complexes are proposed. All the free ligands and their complexes have been tested in vitro against a number of pathogenic fungi and bacteria and were found to possess good fungi cidal and bactericidal properties.